Hepatitis B Virus Dna in Serum From Patients With Acute Hepatitis B
Open Access
- 1 January 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Hepatology
- Vol. 5 (1), 10-13
- https://doi.org/10.1002/hep.1840050104
Abstract
Sera from 77 consecutive patients with acute type B hepatitis were examined for hepatitis B virus DNA (HBV DNA) by a spot hybridization method. The median follow–up time was 8 months (range, 1 week to 3 years). HBV DNA was detected in 26 (34%) patients on admission to the hospital. A significant positive correlation was found between short duration of symptoms and the presence of HBV DNA (p < 0.025). Twenty–four (46%) of 52 HBeAg–positive patients were HBV DNA positive compared to 2 HBV DNA–positive patients of 25 HBeAg–negative patients (8%) (p < 0.001). Four HBeAg–negative patients had serum HBV DNA initially or during follow–up; three had anti–HBe. Six of 77 patients with acute type B hepatitis (8%) became chronic HBsAg carriers, and HBV DNA was detectable from 5 months to more than 3 years after onset of symptoms. The presence of serum HBV DNA for more than 8 weeks after initial symptoms may predict development of a chronic HBsAg carrier state. In none of the chronic carriers was serum HBV DNA present after clearing of HBeAg.Keywords
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