ACCUMULATION OF POLYAMINES AND THEIR WEAK ASSOCIATION WITH LOWER BODY-TEMPERATURE IN ELDERLY CONVALESCENT PATIENTS

Abstract

Because spermine and spermidine have caused hypothermia in rodent experiments, we tested the hypothesis that these polyamines accumulate in some elderly convalescent patients and that this accumulation could predispose to lower body tempeature. Fourteen healthy young, seven healthy older, and 47 convalescent elderly subjects had serum spermine and spermidine concentrations measured by high-pressure liquid chromatography. The mean .+-. SD spermine values were 18 .+-. 10, 24 .+-. 15, and 40 .+-. 54 ng/mg, respectively. The values for spermidine were 28 .+-. 10, 38 .+-. 29, and 76 .+-. 46 ng/ml, respectively. The differences between the young and convalescent elderly were statistically significant for both compounds. Rectal temperatures were measured in 39 elderly convalescent subjects with a thermometer designed for accuracy at low temperatures. These subjects were stratified into a warm and cool half based on a median rectal temperature of 37.degree. C. There was an association between having high spermine levels and being in the cool half of the elderly convalescent group (P < 0.05). We conclude that some elderly convalescent patients have high levels of spermidine and spermine and that these high spermine levels may be associated with lower body temperature.