Motor neuron disease and paraproteinemia
- 1 February 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 37 (2), 335
- https://doi.org/10.1212/wnl.37.2.335
Abstract
We studied two patients with motor neuron disease and paraproteinemia. One had amyotrophic lateral sclerosis (ALS) and IgG lambda monoclonal gammopathy. The second had slowly progressive muscular atrophy and an IgM kappa paraprotein, followed by a biclonal gammopathy when an IgA kappa paraprotein appeared. Treatment with immunosuppressive agents and plasmapheresis lowered the serum concentration of the paraproteins. The ALS syndrome progressed despite therapy. The other patient improved, was stable for several years, but then deteriorated despite continued therapy.This publication has 13 references indexed in Scilit:
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