Characterization of Mutants of Bacillus subtilis Resistant to S-(2-Aminoethyl)cysteine

Abstract

SUMMARY: S-(2-Aminoethyl)-L-cysteine, an analogue of L-lysine, inhibits growth of Bacillus subtilis. Two different mutants resistant to this analogue were isolated. One overproduced lysine and the mutation mapped near ilvC. The other did not overproduce lysine and was unable to express resistance to the analogue in a medium containing threonine; it was linked to the thr-5 marker.