Amino acid sequence changes in the haemagglutinin of A/Hong Kong (H3N2) influenza virus during the period 1968–77
- 1 January 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 283 (5746), 454-457
- https://doi.org/10.1038/283454a0
Abstract
Hemagglutinin molecules from 9 strains of A/Hong Kong/68 (H3N2) influenza virus, isolated between 1968-1977, were examined for changes in amino acid sequences. At least 18 changes, 9 of which were located precisely, occurred in the soluble tryptic peptides of the large hemagglutinin polypeptide (HA1) during this period. These peptides contained 262 residues (82% of HA1). In HA2, only 2 changes in 129 residues (58% of HA2) were detected. Sequential changes at a particular locus were not found; apparently, once an amino acid changed, it did not change again in any subsequent variant examined.Keywords
This publication has 20 references indexed in Scilit:
- GLOBAL SURVEILLANCE OF INFLUENZABritish Medical Bulletin, 1979
- The Carboxyl‐Terminal Sequence of the Heavy Chain of a Hong Kong Influenza HaemagglutininEuropean Journal of Biochemistry, 1978
- Correlation between RNA fragments of fowl plague virus and their corresponding gene functionsVirology, 1976
- Size and chemical composition of influenza virus hemagglutinin chainsFEBS Letters, 1976
- Mapping of the influenza virus genome: identification of the hemagglutinin and the neuraminidase genes.Proceedings of the National Academy of Sciences, 1976
- Studies on the primary structure of the influenza virus hemagglutinin.Proceedings of the National Academy of Sciences, 1975
- Separation of two polypeptide chains from the hemagglutinin subunit of influenza virusVirology, 1971
- An antigenic variant of the Hong Kong/68 influenza A 2 virusEpidemiology and Infection, 1971
- Studies on Marsupial Protein. II. Amino Acid Sequence of the -Chain of Haemoglobin from the Grey Kangaroo, Macropus GiganteusAustralian Journal of Biological Sciences, 1969
- Selection of antigenic mutants of influenza viruses. Isolation and peptide mapping of their hemagglutinating proteinsVirology, 1968