Effect of Reserpine on Oxytocin and Lactogen Discharge in Lactating Rats.

Abstract

1) The effect of reserpine upon release of oxytocin and lactogenic hormone from the hypophysis has been studied in 14-day postpartum lactating rats. Oxytocin discharge, evaluated by milk let-down yield per timed nursing, was significantly inhibited. Results indicate the drug inhibits oxytocin discharge by suppression of central sympathetic centers involved in the let-down reflex. 2) Decrease of pituitary lactogen content (prenursing level) by approximately 48% indicates reserpine stimulates release of lactogenic hormone. It is possible that the effect is mediated by suppression of an inhibitory hypothalamic center controlling lactogen discharge or by direct action of drug upon adenohypophysis.