Translocation Trisomic Mice: Production by Female but Not Male Translocation Carriers

Abstract

In man, there is generally a greater chance for a translocation trisomic child to be born if the mother rather than the father is the translocation carrier. The same type of inheritance has occurred in the mouse. Female mice heterozygous for the reciprocal translocationT(14;15)6Ca have produced a high frequency of translocation trisomic offspring. Male mice heterozygous for the same translocation have produced no translocation trisomic offspring. Thus, the laboratory mouse may provide a model for studying the cause of this phenomenon.