INFLUENCE OF CIRCULATING MALARIAL ANTIGENS ON CELL-MEDIATED-IMMUNITY IN ACUTE PLASMODIUM-FALCIPARUM MALARIA
- 1 September 1986
- journal article
- research article
- Vol. 43 (3), 255-262
Abstract
In a group of Thai patients with P. falciparum acute malaria, circulating malarial antigens (CMA) were detected in 27/33 cerebral malaria (CM) cases and 31/43 noncerebral cases. Delayed cutaneous responses to phytohemagglutinin and candidin were found frequently negative in patients with CMA, especially in the CM group. Mean in vitro lymphocyte proliferative responses to lectins were lower in the group of patients with CMA. An inhibitory activity on proliferative responses to phytohemagglutinin of lymphocytes from healthy individuals was exerted by sera containing CMA. Data suggest that CMA from P. falciparum may suppress in vivo and in vitro cell mediated immune reactions.This publication has 9 references indexed in Scilit:
- Impaired cell-mediated immunity in Plasmodium falciparum-infected patients with high-parasitemia and cerebral malariaClinical Immunology and Immunopathology, 1983
- Cryoglobulins, circulating immune complexes, and complement activation in cerebral malariaInfection and Immunity, 1981
- 2 DISTINCT TYPES OF NONSPECIFIC IMMUNOSUPPRESSION IN MURINE MALARIA1980
- LOSS OF CIRCULATING LYMPHOCYTES-T WITH NORMAL LEVELS OF LYMPHOCYTES-B AND NULL LYMPHOCYTES IN THAI ADULTS WITH MALARIA1979
- IMMUNITY TO PLASMODIUM-BERGHEI-YOELII IN MICE .2. SPECIFIC AND NONSPECIFIC CELLULAR AND HUMORAL RESPONSES DURING COURSE OF INFECTION1978
- IMMUNO-ELECTRO-DIFFUSION ON CELLULOSE-ACETATE MEMBRANE FOR SEROLOGICAL TESTING IN HUMAN MALARIA1978
- PLASMODIUM BERGHEI-INFECTION IN ISOGENIC F1(C57BI X DBA)-MICE .2. ANTIBODIES AND ANTIGENS IN SERUM1976
- PERIPHERAL-LYMPHOCYTE SUBPOPULATIONS IN HUMAN FALCIPARUM MALARIA1976
- GEL-DIFFUSION TEST IN MALARIA - SENSITIVITY AS COMPARED TO IFA-TEST, WITH SOLUBLE-ANTIGENS PREPARED BY DIFFERENT METHODS1975