Identification of Avian Erythroblastosis Virus by Precipitation with Chicken Immune Serum.

Abstract

Spheriodal particles of about 100-120 m[mu] diameter occur characteristically in the plasma of chickens with erythroblastosis. With formalin-inactivated concentrates of these particles, immune serums were produced in the chicken which effectively neutralize the infectivity of the agent. These antiserums also cause agglomeration of particles in concentrates identifiable by electron micrography as those found characteristically in this disease. Results were interpreted to indicate that the characteristic particles agglomerated constitute the viral agent of avian erythroblastosis.