LOCALIZATION OF RADIOACTIVITY OF COLLOIDAL GOLD198

Abstract

ONE OF THE shortcomings of the therapeutic use of radioactive isotopes has been failure of specific localization of activity. Iodine¹³¹is specific for functioning thyroid tissue, but none of the other isotopes has been as specific in its localizing abilities. Phosphorus³²has some affinity for the hematopoietic system and has been used for treatment of certain blood diseases. Gallium has some specificity for bone and has been used for the treatment of bone tumors. Localization of most isotopes has not been as specific as was hoped. In the following work an effort was made to localize radioactivity by local implantation rather than by specific tissue affinity. Work was done on dogs, and the routes used were intraarterial, intravenous, intraperitoneal, intrapleural, and intravesicular. The results are promising enough to warrant presentation of this preliminary report. Colloidal gold¹⁹⁸has been used before, mostly by Paul Hahn and his associates,