Solubilization of Thiazolobenzimidazole Using a Combination of pH Adjustment and Complexation with 2-Hydroxypropyl-β-Cyclodextrin
- 1 January 1993
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 10 (8), 1136-1143
- https://doi.org/10.1023/a:1018908032686
Abstract
The thiazolobenzimidazole l-(2,6-difluorophenyl)-lH,3H-thiazolo[3,4- a]benzimidazole, TBI, is an experimental drug for the treatment of AIDS which exhibits a low water solubility (11 µg/mL) and is...Keywords
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