Entrainment of the Circadian Activity Rhythm to the Light-Dark Cycle Can Be Altered by a Short-Acting Benzodiazepine, Triazolam
- 1 December 1987
- journal article
- research article
- Published by SAGE Publications in Journal of Biological Rhythms
- Vol. 2 (4), 249-260
- https://doi.org/10.1177/074873048700200401
Abstract
The circadian rhythm of locomotor activity in hamsters maintained in either constant darkness or constant light can be phase-shifted by a single injection of the short-acting benzo diazepine, triazolam. These results suggest that treatment with triazolam may also alter the entrainment pattern of circadian rhythms in animals that are synchronized to a light-dark (LD) cycle. To test this hypothesis, hamsters maintained on an LD 6:18 light cycle received daily injections of triazolam (or vehicle) for 10-12 days, and any subsequent effects on the phase relationship between the onset of activity and the LD cycle were determined. Daily injections of triazolam (but not vehicle) induced pronounced advances or delays in the phase relationship between the entrained activity rhythm and the LD cycle; the direction of the shift was dependent on the time of the injection. Taken together with data from previous studies, these results suggest that triazolam, and perhaps other short-acting benzodiazepines, can be used to manip ulate the mammalian circadian clock under a variety of experimental conditions.Keywords
This publication has 21 references indexed in Scilit:
- Effects of diazepam on circadian phase advances and delaysBrain Research, 1986
- Bicuculline blocks circadian phase delays but not advancesBrain Research, 1985
- The suprachiasmatic nucleus of the golden hamster: Immunohistochemical analysis of cell and fiber distributionNeuroscience, 1984
- Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythmsNature, 1984
- Effects of chronic lithium, clorgyline, imipramine, fluphenazine and constant darkness on the α-melanotropin content and circadian rhythm in rat brainEuropean Journal of Pharmacology, 1982
- Effect of Lithium on Circadian Neurotransmitter Receptor RhythmsNeuropsychobiology, 1982
- Lithium Delays Biochemical Circadian Rhythms in RatsNeuropsychobiology, 1982
- Light-dark entrainment of proestrous LH surges and circadian locomotor activity in female hamstersHormones and Behavior, 1981
- Changes in locomotor activity associated with the photoperiodic response of the testes in male golden hamstersJournal of Comparative Physiology A, 1979
- A Functional analysis of circadian pacemakers in nocturnal rodentsJournal of Comparative Physiology A, 1976