On the Possible Involvement of Ascorbic Acid and Copper Proteins in Leukemia. III. ESR Investigations on the Interaction between Ascorbic Acid and Some Transition Metal Ions
Open Access
- 1 August 1979
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 34 (7-8), 546-549
- https://doi.org/10.1515/znc-1979-7-809
Abstract
The interaction between lyophilized samples of ascorbic acid and Cu2+, Fe3+ or Mn2+ was investigated by ESR spectroscopy. All of the 3 transition metal ions form complexes with vitamin C, but in the case of Cu2+ and Fe3+ the interaction results in a reduction of the metal ions. Cu2+ and ascorbic acid seem to form 2:1 complexes with an equilibrium constant of .apprx. K = 1 .times. 107 mol-1. None of these metal ion complexes exhibits the ESR spectrum obtained with leukemic blood. [The ESR spectra of lyophilized blood of leukemia patients exhibit an increase in spin concentration. Vitamin C added to blood produces a spectrum which is identical to the one obtained from blood of leukemic patients. To elucidate this mechanism the effect of vitamin C on metal ions was studied.].Keywords
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