A comparison of artificial saliva and pilocarpine in radiation induced xerostomia
- 1 August 1994
- journal article
- clinical trial
- Published by Cambridge University Press (CUP) in The Journal of Laryngology & Otology
- Vol. 108 (8), 663-665
- https://doi.org/10.1017/s0022215100127768
Abstract
Twenty patients with radiation-induced xerostomia were entered into a prospective randomized crossover study comparing a mucin-based artificial saliva (Saliva Orthana) and a mouthwash containing pilocarpine 5 mg three times a day. Overall the patients found that the pilocarpine mouthwash was more effective than the artificial saliva in relieving their symptoms (p = 0.04), and 47 per cent of the patients wanted to continue with this treatment after the study had finished.Keywords
This publication has 9 references indexed in Scilit:
- Oral Pilocarpine for Post-Irradiation Xerostomia in Patients with Head and Neck CancerNew England Journal of Medicine, 1993
- A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients.Journal of Clinical Oncology, 1993
- Pilocarpine and other cholinergic drugs in the management of salivary gland dysfunctionOral Surgery, Oral Medicine, Oral Pathology, 1993
- Pilocarpine and carbacholine in treatment of radiation-induced xerostomiaRadiotherapy and Oncology, 1993
- Pilocarpine oral solutionBritish Dental Journal, 1991
- Effectiveness of pilocarpine in postradiation xerostomiaCancer, 1987
- A double-blind crossover trial of CMC- and mucin-containing saliva substitutesInternational Journal of Oral & Maxillofacial Surgery, 1986
- Pilocarpine for the treatment of xerostomia associated with salivary gland dysfunctionOral Surgery, Oral Medicine, Oral Pathology, 1986
- The effect of mucin-containing artificial saliva on severe xerostomiaInternational Journal of Oral Surgery, 1974