Isocarboxazid Metabolism in Rat Liver Homogenate

Abstract

Isocarboxazid was extensively metabolized under aerobic or anaerobic conditions in an in vitro system containing rat liver homogenate as the enzyme source. Benzylhydrazine was a major product of this metabolism as determined by paper chromatography and reverse isotope dilution in studies with C14-isocarboxazid. The possible occurrence of this pathway in vivo was discussed.