Retinal Pigment Epithelial Cells Release an Inhibitor of Neovascularization
- 1 December 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 103 (12), 1870-1875
- https://doi.org/10.1001/archopht.1985.01050120104029
Abstract
• Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.This publication has 19 references indexed in Scilit:
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