The yield of subtelomeric FISH analysis in the evaluation of autistic spectrum disorders
- 17 January 2006
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part C-Seminars In Medical Genetics
- Vol. 142C (1), 8-12
- https://doi.org/10.1002/ajmg.c.30077
Abstract
To assess the frequency of cryptic subtelomeric rearrangements in children and adolescents with autism spectrum disorders, blood samples were studied using a complete set of subtelomeric FISH probes in 72 children with autism spectrum disorders. All children had normal high resolution karyotype, DNA fra‐X analysis, brain MRI, metabolic work‐up, and physical/neirological examination. Subtelomeric analysis did not detect abnormalities in any of the subjects, suggesting the uselessness of such investigations in individuals with primary autism spectrum disorders.Keywords
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