Long-Lived Charge-Separated State Leading to DNA Damage through Hole Transfer
- 1 December 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (52), 16198-16199
- https://doi.org/10.1021/ja038309g
Abstract
The hole transfer causes the long-lived charge-separated state in DNA during the photosensitized one-electron oxidation of DNA. The combination of the transient absorption measurement and DNA damage quantification by HPLC clearly demonstrated that the yield of the DNA damage correlates well with the lifetime of the charge-separated state.Keywords
This publication has 26 references indexed in Scilit:
- Direct Observation of Guanine Radical Cation Deprotonation in Duplex DNA Using Pulse RadiolysisJournal of the American Chemical Society, 2003
- Fast Back Electron Transfer Prevents Guanine Damage by Photoexcited Thionine Bound to DNAJournal of the American Chemical Society, 2003
- Kinetics of Weak Distance-Dependent Hole Transfer in DNA by Adenine-Hopping MechanismJournal of the American Chemical Society, 2003
- Photodynamic therapy for cancerNature Reviews Cancer, 2003
- Possible cause of G·C→C·G transversion mutation by guanine oxidation product, imidazoloneChemistry & Biology, 2001
- Direct Spectroscopic Observation of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine Radicals in Double-Stranded DNA Generated by One-Electron Oxidation at a Distance by 2-Aminopurine RadicalsThe Journal of Physical Chemistry B, 2000
- Oxidative Repair of a Thymine Dimer in DNA from a Distance by a Covalently Linked Organic IntercalatorJournal of the American Chemical Society, 2000
- Photoprocesses of Naphthalene Imide and Diimide Derivatives in Aqueous Solutions of DNAJournal of the American Chemical Society, 2000
- Chemistry of Sequence-Dependent Remote Guanine Oxidation: Photoreaction of Duplex DNA Containing Cyanobenzophenone-Substituted UridineJournal of the American Chemical Society, 1999
- Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodGNature, 1991