Highly Enantioselective Conjugate Addition of Nitromethane to Chalcones Using Bifunctional Cinchona Organocatalysts
Top Cited Papers
- 14 April 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (10), 1967-1969
- https://doi.org/10.1021/ol050431s
Abstract
Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.Keywords
This publication has 11 references indexed in Scilit:
- Conjugate Additions of Nitroalkanes to Electron-Poor Alkenes: Recent ResultsChemical Reviews, 2005
- Highly Efficient Dynamic Kinetic Resolution of Azlactones by Urea‐Based Bifunctional OrganocatalystsAngewandte Chemie International Edition, 2005
- Bifunctional Lewis Acid-Nucleophile-Based Asymmetric Catalysis: Mechanistic Evidence for Imine Activation Working in Tandem with Chiral Enolate Formation in the Synthesis of β-LactamsJournal of the American Chemical Society, 2005
- In the Golden Age of OrganocatalysisAngewandte Chemie International Edition, 2004
- Asymmetric Organic Catalysis with Modified Cinchona AlkaloidsAccounts of Chemical Research, 2004
- Synthesis and investigation of a hindered, chiral, bicyclic guanidineTetrahedron: Asymmetry, 1995
- Catalytic asymmetric Michael addition of nitroalkane to enone and enalTetrahedron Letters, 1994
- Encoding and decoding hydrogen-bond patterns of organic compoundsAccounts of Chemical Research, 1990
- High-pressure asymmetric Michael additions of thiols, nitromethane, and methyl oxoindancarboxylate to enonesThe Journal of Organic Chemistry, 1988
- Addition of aromatic thiols to conjugated cycloalkenones, catalyzed by chiral .beta.-hydroxy amines. A mechanistic study of homogeneous catalytic asymmetric synthesisJournal of the American Chemical Society, 1981