Chlorpromazine Dermatitis

Abstract

CHLORPROMAZINE contact dermatitis has become an important occupational hazard of nursing. This drug, particularly in the form of its injectable solution, is a potent cutaneous sensitizer, and nursing personnel with exposure ordinarily occurring in the course of administering such injections, in cleaning syringes or indeed merely from the fumes of opened vials are frequently afflicted with severe and at times prolongedly disabling eruptions. Furthermore, immunochemical relations existing between chlorpromazine and certain other commonly used drugs, most notably other phenothiazine derivatives, may result in cross-sensitizations clinically important in causing cryptic recurrences.Case ReportH.M., a 44-year-old nurse, was first seen on . . .