Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.
Open Access
- 1 July 1983
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 158 (1), 1-8
- https://doi.org/10.1084/jem.158.1.1
Abstract
Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 days developed classic graft-vs.-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA; normal rats did not. Syngeneic GVHD was transferred to irradiated, but not normal, syngeneic recipients. Normal spleen cells failed to prevent the development or adoptive transfer of syngeneic GVHD.This publication has 13 references indexed in Scilit:
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