Chronic Alcohol Consumption Increases Cyclo (His‐Pro)‐Like Immunoreactivity in the Rat Brain
- 31 May 1982
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 38 (6), 1785-1786
- https://doi.org/10.1111/j.1471-4159.1982.tb06666.x
Abstract
Administration of histidyl-proline diketopiperazine (cyclo (HisPro)) to rats attenuates ethanol-induced sleep. To understand the role played by cyclo (His-Pro) in the pathophysiology of prolonged alcohol consumption, we have measured the distribution of this peptide in brains of control and alcohol-treated rats. The data show that prolonged alcohol consumption increases the concentration of cyclo (His-Pro) in hypothalamic as well as extrahypothalamic brain. These changes may reflect a physiologic adaptation of the brain during alcohol consumption.Keywords
This publication has 15 references indexed in Scilit:
- Antagonism of ketamine-induced anesthesia and hypothermia by thyrotropin releasing hormone and cyclo(His-Pro)Neuropharmacology, 1981
- Inhibition of abstinence syndrome in opiate defendent mice by cyclo (His-Pro)Life Sciences, 1981
- Cyclo (His-Pro): A selective inhibitor of rat prolactin secretionLife Sciences, 1980
- Histidyl-proline diketopiperazine, an endogenous brain peptide that inhibits (Na+ + K+)-ATPaseBiochemical and Biophysical Research Communications, 1980
- The effects of thyrotropin releasing hormone and histidyl-proline diketopiperazine on delta-9-tetrahydrocannabinol-induced hypothermiaLife Sciences, 1980
- Antagonism of ethanol-induced decrease in rat brain cGMP concentration by histidyl-proline diketopiperazine, a thyrotropin releasing hormone metaboliteBiochemical and Biophysical Research Communications, 1979
- Thermoregulation in rats: Opposing effects of thyrotropin releasing hormone and its metabolite histidyl-proline diketopiperazineBiochemical and Biophysical Research Communications, 1978
- Psychopharmacology of AlcoholAnnual Review of Pharmacology and Toxicology, 1978
- Antagonism of ethanol narcosis by histidyl-proline diketopiperazineNature, 1977
- REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐IJournal of Neurochemistry, 1966