Synergistic Antiproliferative Effect of Interferon-β in Combination with Bleomycin or Neocarzinostatin on HeLa Cells in Culture: Additive Effect When Combined with Adriamycin or Mitomycin C
- 1 August 1987
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 7 (4), 419-425
- https://doi.org/10.1089/jir.1987.7.419
Abstract
Human fibroblast interferon (IFN)-.beta. was administered in combination with the free radical-generating antiproliferative agents bleomycin (BLM), neocarzinostatin (NCS), adriamycin (ADM), and mitomycin C (MMC) to HeLa cells in culture. IFN showed a true synergistic antiproliferative activity in the presence of BLM or NCS. These effects were observed regardless of the ratio of IFN to BLM or NCS concentrations. However, the effect of IFN in the presence of ADM or MMC was additive. The possibility that IFN-.beta. potentiates the antiproliferative effects of these free radical-generating agents in a different manner is also discussed.This publication has 41 references indexed in Scilit:
- Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: Genetic difference in the responses of miceBiochemical and Biophysical Research Communications, 1985
- In vitro studies on potentiation of cytotoxic effects of anticancer drugs by interferon on a human neoplastic cell line (HeLa)Cancer Letters, 1983
- On the biochemical similarities of ascorbic acid and interferonJournal of Theoretical Biology, 1982
- Electron spin resonance detection of free radicals in the mercaptan-activation and UV-inactivation of neocarzinostatinBiochemical and Biophysical Research Communications, 1981
- The production of hydroxyl radical by bleomycin and iron (II)FEBS Letters, 1979
- Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue cultureInternational Journal of Cancer, 1977
- A role for ferrous ion and oxygen in the degradation of DNA by bleomycinBiochemical and Biophysical Research Communications, 1976
- release of thymine from DNA by neocarzinostatinBiochemical and Biophysical Research Communications, 1976
- Increased DNA chain breakage by combined action of bleomycin and superoxide radicalBiochemical and Biophysical Research Communications, 1975
- DNA strand scission by the antitumor protein neocarzinostatinBiochemical and Biophysical Research Communications, 1974