Protective effects of anti‐C5a peptide antibodies in experimental sepsis
Open Access
- 19 January 2001
- journal article
- fj express-summary
- Published by Wiley in The FASEB Journal
- Vol. 15 (3), 568-570
- https://doi.org/10.1096/fj.00-0653fje
Abstract
We evaluated antibodies to different peptide regions of rat C5a in the sepsis model of cecal ligation and puncture (CLP) for their protective effects in rats. Rabbit polyclonal antibodies were develo...Keywords
Funding Information
- National Institutes of Health (GM‐29507, GM‐31963)
This publication has 38 references indexed in Scilit:
- Effects of anti‐C5a monoclonal antibodies on oxygen use in a porcine model of severe sgifisEuropean Journal of Clinical Investigation, 1998
- Inhibition of interleukin‐6 synthesis in an animal model of septic shock by anti‐C5a monoclonal antibodiesEuropean Journal of Immunology, 1996
- Site‐specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptorEuropean Journal of Biochemistry, 1994
- P-selectin and platelet-activating factor mediate initial endotoxin-induced neutropenia.The Journal of Experimental Medicine, 1994
- Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndromeClinical and Experimental Immunology, 1990
- Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance dataBiochemistry, 1989
- The Effect of Trauma on Serum C3 Activation and its Correlation with Injury Severity Score in ManPublished by Wolters Kluwer Health ,1986
- The Role of C5 in Septic Lung InjuryAnnals of Surgery, 1985
- Primate erythrocyte-immune complex-clearing mechanism.Journal of Clinical Investigation, 1983
- Profile of Complement Components in Patients with Severe BurnsPublished by Wolters Kluwer Health ,1980