Docetaxel: Overview of an Active Drug for Breast Cancer
- 1 June 2001
- journal article
- review article
- Published by Oxford University Press (OUP) in The Oncologist
- Vol. 6 (S3), 1-4
- https://doi.org/10.1634/theoncologist.6-suppl_3-1
Abstract
Docetaxel and paclitaxel differ in their precise molecular targets and pharmacokinetics. Docetaxel is more avidly taken up by tumor cell lines than paclitaxel, and its efflux is slower. Comparative cytotoxicity data suggest greater potency. These factors may help explain the clinical differences that have been observed between the taxanes in patients with breast cancer.Keywords
This publication has 14 references indexed in Scilit:
- Chemotherapy of breast cancer: are the taxanes going to change the natural history of breast cancer?Expert Opinion on Pharmacotherapy, 2000
- Prospective Randomized Trial of Docetaxel Versus Doxorubicin in Patients With Metastatic Breast CancerJournal of Clinical Oncology, 1999
- Docetaxel compared with sequential methotrexate and 5-fluorouracil in patients with advanced breast cancer after anthracycline failure: a randomised phase III study with crossover on progression by the Scandinavian Breast GroupEuropean Journal Of Cancer, 1999
- Prospective Randomized Trial of Docetaxel Versus Mitomycin Plus Vinblastine in Patients With Metastatic Breast Cancer Progressing Despite Previous Anthracycline-Containing ChemotherapyJournal of Clinical Oncology, 1999
- Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.Journal of Clinical Oncology, 1998
- Preclinical pharmacokinetics of paclitaxel and docetaxelAnti-Cancer Drugs, 1998
- Docetaxel (Taxotere®) a review of preclinical and clinical experience. Part IAnti-Cancer Drugs, 1995
- Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: Reversibility, ligand stoichiometry, and competitionBiochemistry, 1993
- Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of TaxolJNCI Journal of the National Cancer Institute, 1991
- Taxol: an antimitotic agent with a new mechanism of actionPharmacology & Therapeutics, 1984