Model for the Rh Blood Group System Based on Discontinuous Gene Structure
- 1 August 1981
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 41 (2), 102-109
- https://doi.org/10.1111/j.1423-0410.1981.tb01022.x
Abstract
A model of the human Rh blood group system is proposed which is based on discontinuous gene structure. The R29 control subregion consists of a single exon flanked by introns. Following the R29 subregion, the R1 subregion exists as 7 exon structures which alternate with introns. The expression of each exon is controlled by flanking introns. A separate exon-intron structure controls expression of the Rh: -1 phenotype. Differential gene expression is controlled by intron sequences and complementary splicer RNA sequences encoded by unlinked loci.This publication has 38 references indexed in Scilit:
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