Therapeutic Effectiveness of Single and Divided Doses of Penicillin in a Streptococcal Infection in Mice

Abstract

From 4 to 8 times as much penicillin was needed for oral as for subcut. adm., to obtain the same degree of therapeutic effect in a streptococcal infection in mice. In this infection, adm. of daily penicillin dosage in a series of small equally spaced doses was not more effective than giving an equiv. amt. of drug in 1 or 2 doses per day.