Renal Glutaminase and Carbonic Anhydrase Activities in Potassium-Deficient Rats.

Abstract

Kidney glutaminase and carbonic anhydrase activities were determined in intact and adrenalectomized rats maintained on normal and K-deficient diets, with and without simultaneous administration of desoxycorticosterone acetate. The changes of enzyme activity could not be related to plasma and muscle electrolytes. The activities of the two enzymes were unaltered in adrenalectomized rats fed the control diet and allowed 0.25 [image] NaCl ad libitum. Experimental conditions resulting in increased glutaminase activity in adrenalectomized rats had the same response to a greater degree in intact rats. Kidney carbonic anhydrase activity failed to increase in adrenalectomized rats under circumstances which in intact rats led to increased activity.