In vitro Comparison of the Erythrocyte Sedimenting Properties of Dextran, Hydroxyethyl Starch and a New Low‐Molecular‐Weight Hydroxyethyl Starch
- 1 November 1979
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 37 (5), 268-271
- https://doi.org/10.1111/j.1423-0410.1979.tb02303.x
Abstract
A low‐molecular‐weight preparation of hydroxyethyl starch (LMW‐HES) may serve as a desirable substitute for the erythrocyte sedimenting agents presently employed to improve neutrophil yields in centrifugation and gravity leukapheresis. The cell‐separating and erythrocyte‐sedimenting properties of LMW‐HES, assessed in vitro by the recovery of various blood cells in plasma supernatant fluids, were similar to those of the higher‐molecular‐weight hydroxyethyl starch in current use and to dextran under a variety of conditions. These data predict success for LMW‐HES as a sedimenting agent in leukapheresis and recommend that it be evaluated in clinical trials.This publication has 6 references indexed in Scilit:
- Gravity leukapheresis—A simple method of leukocyte collection for transfusion or in vitro studyLeukemia Research, 1979
- A Standardized Technique for Efficient Platelet and Leukocyte Collection Using the Model 30 Blood ProcessorTransfusion, 1976
- Intravascular Persistence of Hydroxyethyl Starch in ManEuropean Surgical Research, 1976
- Anaphylactoid Reactions Due to Hydroxyethyl Starch InfusionEuropean Surgical Research, 1976
- Increased Efficiency of Leukocyte Collection by the Addition of Hydroxyethyl Starch to the Continuous Flow CentrifugeBlood, 1974