In vitro Studies of the Mechanism of Polyuria Induced by Dextro Propoxyphene (Darvon).

Abstract

Summary The isolated surviving toad bladder was used to demonstrate direct peripheral antagonism between antidiuretic hormone and both dextro propoxyphene (Darvon®) and levo propoxyphene (Norvad®). These findings suggest that the polyuria accompanying a recent death after dextro propoxyphene ingestion was a result of drug-induced nephrogenic diabetes insipidus.