ON THE TRANSPLANTATION OF THE GUINEA PIG SUPRARENAL AND THE FUNCTIONING OF THE GRAFTS

Abstract

1. The suprarenal cortex of the guinea pig can be transplanted autoplastically into the abdominal wall and may remain for months, growing to fairly large size. 2. The suprarenal cortex of the guinea pig can be transplanted homoplastically but these transplants usually degenerate after a few months. 3. Small autoplastic transplants are capable of maintaining the life of a completely suprarenalectomized guinea pig for weeks and large transplants maintain the animal indefinitely in good condition. 4. Irritation phenomena follow the grafting of suprarenal cortex due to the entrance of epinephrine into this tissue during the manipulation involved in removal of the gland.