Radioimmunoassay of Fibrinopeptides in Relation to Intravascular Coagulation and Thrombosis

Abstract

The action of thrombin on fibrinogen and platelets is thought to play a critical part in thrombosis. Thrombin action has been implicated in the pathogenesis of disseminated intravasacular coagulation and of certain chronic renal diseases, and it may also be involved in rejection of renal transplants. Drugs can be used to neutralize thrombin and prevent its formation. Since measurements of thrombin activity should be helpful in selecting patients for anticoagulant therapy and in monitoring its effectiveness, my colleagues and I have developed assays for fibrinopeptides A and B, which provide evidence of thrombin action in vivo. These assays reflect specific . . .