Experimental transcatheter splenectomy using absolute ethanol.

Abstract

Since ethanol is known to be effective for transcatheter infarction of the kidney, it was evaluated as an agent for splenic ablation in swine and dogs. Infarction was successful in 7 of 9 pigs and 4 of 5 dogs. Controlled segmental infarction using flow-directed balloon catheters was attempted and was successful in 3 pigs and 2 dogs. The maximum blood ethanol level was 78 mg/100 ml, and by 15 min after injection it was .ltoreq. 20 mg/100 ml. There was no evidence of pancreatic or hepatic injury at autopsy. With careful catheter positioning, controlled total or partial infarction of the spleen can be safely performed with absolute ethanol without risk of abscess formation, pneumonia, or significant damage to other organs. [This may be useful in the treatment of hypersplenism.].