Structural studies on optical resolution via diasteroisomeric salt formation. Enantiomer separation for cis-permethrinic acid [cis-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylic acid]

Abstract

The pH dependence of enantiomer separation by optical resolution of cis-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylic acid (I) with (S)-2-benzylaminobutanol (II) has been investigated. Thermodynamic constants, thermal behaviour, and the molecular and crystal structure were determined in order to evaluate and interpret the results of optical resolution.