The Association between Plasma GIP and Insulin after Oral Glucose

Abstract

The correlation between the peripheral concentrations of gastric inhibitory polypeptide (GIP), insulin and glucose was not previously quantified. The association among the peripheral concentrations of GIP, insulin and glucose during 50-g oral glucose tolerance tests (OGTT) in healthy volunteers and in patients with gastrointestinal disorders, obesity and uremia is described. The correlation between insulin/glucose and plasma GIP concentrations during an OGTT can apparently be expressed by an equation. This empirical correlation between [insulin]/[glucose] and [GIP] reduces the plasma parameters measured during OGTT to a simple relationship. It may prove valuable in the analysis of differences in the relationship glucose-insulin-GIP between groups of subjects and in the description of alterations in glucose homeostasis longitudinally in individuals undergoing therapy.