3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin
- 1 November 1991
- journal article
- review article
- Published by Cambridge University Press (CUP) in Canadian Journal of Neurological Sciences
- Vol. 18 (4), 492-498
- https://doi.org/10.1017/s0317167100032212
Abstract
3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.Keywords
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