Influence of Imipramine-like Compounds and Chlorpromazine on the Reserpine-Hypothermia in Mice and the Amphetamine-Hyperthermia in Rats

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Abstract
The difference between imipramine-like antidepressant agents and chlorpromazine in antagonizing the reserpine-induced hypothermia in mice was found to be merely quantitative. In contrast thereto, opposite effects were observed with respect to the amphetamine-induced hyperthermia in rats which was potentiated by antidepressant agents and inhibited by chlorpromazine.