Complications of chronic levodopa therapy
- 1 April 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 31 (4), 473
- https://doi.org/10.1212/wnl.31.4.473
Abstract
Chronic use of levodopa may be complicated by dyskinesias, on-off effect, or hallucinosis. Transient levodopa withdrawal (drug holiday) may increase motor responsiveness and decrease levo-dopa-induced side effects, and the improved state may persist for as long as 9 months. After 1 year, parkinsonian signs approached pre-holiday levels, and two of the patients required a 'second drug holiday; side effects began to reappear 9 to 12 months after the holiday. Four of six patients with psychiatric complications remained free of hallucinations for the entire year.This publication has 4 references indexed in Scilit:
- Early-Morning DystoniaArchives of Neurology, 1979
- Considerations in the management of parkinsonismNeurology, 1978
- Central dopaminergic receptor supersensitivity and its relevance to Parkinson's diseaseJournal of the Neurological Sciences, 1977
- Five Years' Treatment of Parkinson's Disease with LevodopaAnnals of Internal Medicine, 1975