Transcriptional control of brown adipocyte development and physiological function—of mice and men
- 1 April 2009
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 23 (7), 788-797
- https://doi.org/10.1101/gad.1779209
Abstract
The last several years have seen an explosion of information relating to the transcriptional control of brown fat cell development. At the same time, new data have emerged that clearly demonstrate that adult humans do indeed have substantial amounts of functioning brown adipose tissue (BAT). Together, these advances are stimulating a reassessment of the role of brown adipose tissue in human physiology and pathophysiology. These data have also opened up exciting new opportunities for the development of entirely novel classes of therapeutics for metabolic diseases like obesity and type 2 diabetes.Keywords
This publication has 114 references indexed in Scilit:
- Distinct expression of muscle‐specific MicroRNAs (myomirs) in brown adipocytesJournal of Cellular Physiology, 2008
- New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditureNature, 2008
- PRDM16 controls a brown fat/skeletal muscle switchNature, 2008
- The Transcriptional Corepressor RIP140 Regulates Oxidative Metabolism in Skeletal MuscleCell Metabolism, 2007
- Transcriptional Control of Brown Fat Determination by PRDM16Cell Metabolism, 2007
- Transcriptional control of adipocyte formationCell Metabolism, 2006
- Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factorCell, 1994
- Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin geneNature, 1993
- Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisNature, 1992
- Effects of an Rb mutation in the mouseNature, 1992