Interaction between the effects of spinal heating and cooling and of injections into a lateral cerebral ventricle of noradrenaline, 5‐hydroxytryptamine and carbachol on thermoregulation in sheep.
- 1 January 1976
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 254 (1), 213-227
- https://doi.org/10.1113/jphysiol.1976.sp011230
Abstract
1. A study has been made of the interactions of the thermoregulatory effects of spinal cord heating and cooling and of the injections into the cerebral ventricle of noradrenaline, 5-hydroxytryptamine (5-HT) and carbamylcholine in sheep. 2. The interactions of spinal cord heating and the injections into the cerebral ventricle of noradrenaline, 5-HT and carbamylcholine were very similar to those of hypothalamic heating or of high ambient temperature and the injections into the cerebral ventricle of these substances. These results are interpreted as evidence of the synaptic convergence of the pathways from peripheral, spinal cord and hypothalamic warm-sensors at or before the points of action of these synaptically active substances. 3. The only definite thermoregulatory effect of spinal cooling was the onset of shivering which could be due to a purely spinal effect of cold. No substantial evidence was obtained of an interaction between spinal cooling and an injection of noradrenaline, 5-HT or carbamylcholine into the cerebral ventricle. Thus there was no clear indication of centripetal pathways from spinal cold sensors converging with those from the skin and the hypothalamus for which evidence of convergence was obtained in an earlier study. 4. The results of this study are expressed in terms of the neuronal model of Bligh, Cottle & Maskrey (1971) and Maskrey & Bligh (1971), appropriately modified.Keywords
This publication has 16 references indexed in Scilit:
- The effect of spinal and skin temperatures on the firing rate and thermosensitivity of preoptic neuronesThe Journal of Physiology, 1974
- Independence of spinal cord and medulla oblongata on thermal activityAmerican Journal of Physiology-Legacy Content, 1974
- Thermoregulatory responses of decerebrate and spinal catsExperimental Neurology, 1974
- Cold sensitivity in the spinal cord of sheepPflügers Archiv - European Journal of Physiology, 1973
- Balanced and unbalanced temperature signals generated in spinal cord of the oxAmerican Journal of Physiology-Legacy Content, 1972
- Spinal cord and hypothalamus as core sensors of temperature in the conscious dogPflügers Archiv - European Journal of Physiology, 1971
- Sensory transmission of spinal heat and cold sensitivity in ascending spinal neuronsPflügers Archiv - European Journal of Physiology, 1971
- The stimulation of hypothalamic neurones by changes in ambient temperaturePflügers Archiv - European Journal of Physiology, 1970
- Improved techniques for the chronic cannulation of the lateral cerebral ventricle and the cisterna magna of the Welsh Mountain sheep.1969
- Temperature-sensitive neurons in preoptic-anterior hypothalamic region: effects of increasing ambient temperatureAmerican Journal of Physiology-Legacy Content, 1968