Review of central nervous system pathology in human immunodeficiency virus infection
- 1 January 1988
- journal article
- review article
- Published by Wiley in Annals of Neurology
- Vol. 23 (S1), S54-S57
- https://doi.org/10.1002/ana.410230715
Abstract
Aseptic meningitis, subacute encephalitis, and vacuolar myelopathy are the three diseases of the central nervous system that are specifically related to or associated with human immunodeficiency virus (HIV) infection. HIV encephalitis initially is associated with myelin pallor and gliosis of the centrum semiovale, which is found in more than 90% of brains from patients dying with the acquired immunodeficiency syndrome. With increased severity of disease, multiple glial nodules with the multinucleated cells characteristic of HIV encephalitis are present throughout the cerebral white matter, basal ganglia, and cerebral cortex, and also may be found in cerebellum, brainstem, and spinal cord. HIV has been demonstrated in monocytes and multinucleated cells by electron microscopy, immunohistochemical techniques, and in situ hybridization. Vacuolar myelopathy occurs in approximately 30% of patients and is characterized by vacuolation of the white matter of the spinal cord that is most prominent in the posterior and lateral columns at thoracic levels. The severity of the pathological lesions correlates not only with symptoms and signs of spinal cord disease but also with dementia. Although the incidence of vacuolar myelopathy is increased in patients with HIV encephalitis, its etiology is not yet established.Keywords
This publication has 31 references indexed in Scilit:
- Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with EncephalopathyScience, 1986
- HTLV-III and Vacuolar MyelopathyNew England Journal of Medicine, 1986
- HTLV-III/LAV Infection of the Central Nervous System in a 57-Year-Old Man with Progressive Dementia of Unknown CauseNew England Journal of Medicine, 1986
- Intra-Blood–Brain-Barrier Synthesis of HTLV-III-Specific IgG in Patients with Neurologic Symptoms Associated with AIDS or AIDS-Related ComplexNew England Journal of Medicine, 1985
- Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1985
- Vacuolar Myelopathy Pathologically Resembling Subacute Combined Degeneration in Patients with the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1985
- Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UCSF and review of the literatureJournal of Neurosurgery, 1985
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patientsAnnals of Neurology, 1983
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983