MPTP-Induced Neurotoxicity and the Quest for a Preventative Therapy for Parkinson's Disease
- 1 February 1991
- journal article
- review article
- Published by Cambridge University Press (CUP) in Canadian Journal of Neurological Sciences
- Vol. 18 (1), 77-82
- https://doi.org/10.1017/s0317167100031346
Abstract
Less than 10 years have passed since the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is capable of producing parkinsonism in both humans and non-human primates. In that time, there has been considerable interest in the possibility that the pathogenesis of idiopathic Parkinson's disease (PD) might involve a process analogous to that of MPTP toxicity. One hypothesis holds that PD might arise, at least in part, from exposure to an MPTP-like environmental toxin. Rapid progress has been made towards elucidating the precise mechanism by which MPTP exerts toxicity, and clarifying the relationship of MPTP toxicity to idiopathic PD. The goal of these efforts is to develop a therapy that inhibits the underlying disease process in PD.Keywords
This publication has 70 references indexed in Scilit:
- Astrocytes as a primary locus for the conversion MPTP into MPP+Journal of Neural Transmission, 1989
- Potentiation by reserpine and tetrabenazine of brain catecholamine depletions by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in the mouse; evidence for subcellular sequestration as basis for cellular resistance to the toxicantNeuroscience Letters, 1988
- 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Metabolism and l-Methyl-4-Phenylpyridinium Uptake in Dissociated Cell Cultures from the Embryonic MesencephalonJournal of Neurochemistry, 1988
- Evidence for neuromelanin involvement in MPTP-induced neurotoxicityNature, 1987
- Astrocytes convert the parkinsonism inducing neurotoxin, MPTP, to its active metabolite, MPP+Neuroscience Letters, 1987
- II. Neuromelanin: A role in MPTP-induced neurotoxicityLife Sciences, 1987
- Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatumNeuroscience Letters, 1985
- Catecholamine-uptake inhibitors prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse brainNeuropharmacology, 1985
- Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.Proceedings of the National Academy of Sciences, 1985
- Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTPEuropean Journal of Pharmacology, 1984