Replacement Time for Alveolar Lipid Removed by Pulmonary Lavage: Effects of Mutliple Lavage on Lung Lipids
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Archives of Physiology and Biochemistry
- Vol. 83 (2), 261-269
- https://doi.org/10.3109/13813457509081870
Abstract
Daily washing in vivo of the lung with 0.15 M saline did not deplete the Beagle dog lung of surfactant lipids, but rather increased the quantity of surfactant lipid in the tissue. Replacement time for the lung lipids removed by the lavage was approximately 5 hours. This rate is one indication of the time required for movement of surfactant lipid from storage areas to the surface of the alveoli. The increase in tissue surfactant lipid following multiple lavage suggests that the rate of surfactant lipid synthesis is controlled in part by the level of surfactant lipid in the alveoli.Keywords
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