Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs
- 16 March 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 8 (9), 2252-2259
- https://doi.org/10.1039/c001307b
Abstract
The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels–Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.This publication has 53 references indexed in Scilit:
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