A histidine-rich protein from Plasmodium falciparum and its interaction with membranes.

Abstract

In previous studies, an unusual protein with 70% of histidine was isolated from Plasmodium lophurae. It was shown to have a possible function in the penetration of merozoites into erythrocytes. The results of the present study indicate the presence of a similar histidine-rich protein in Plasmodium falciparum. Like that of P. lophurae, the histidine-rich protein of P. falciparum is acid-soluble, but it has a slightly higher molecular weight.