THE VASOMOTOR EFFECT OF ACETYLCHOLINE ON THE STOMACH OF THE DOG

Abstract

The excised stomach of a smaller dog was perfused by a larger perfused dog, and measurement of the rate of blood flow through the small stomach was made with the method of Bar-croft and Kato, or the bloodflow through an innervated stomach of a dog was similarly measured in situ; on-cometry of viyiperfused stomachs was performed. Acetylcholine was injected into the gastric artery. In 17 of these expts. (63%) small doses of acetylcholine decreased the rate of bloodflow, while larger doses increased it. In 3 expts. only diminution of flow, and in 7 expts. only increase of flow was observed. The bearing of these results on the genesis of peptic ulcer is discussed.