A free fatty acid – free thyroxine relationship in serum

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Abstract
Serum free fatty acid (FFA) and free thyroxine (T4) levels were measured in six healthy Army volunteers after exercise, and in rats fasted for 24 and 48 h or exposed to 4 °C for 3 and 6 h. A close relationship between FFA and free T4 values was found in humans and rats. It is suggested that this phenomenon may be a displacement of bound T4 from its binding sites by FFA resulting in short-term changes in metabolically available T4.