FLT3: ITDoes matter in leukemia
Top Cited Papers
Open Access
- 1 September 2003
- journal article
- review article
- Published by Springer Nature in Leukemia
- Vol. 17 (9), 1738-1752
- https://doi.org/10.1038/sj.leu.2403099
Abstract
FMS-like tyrosine kinase-3 (FLT3), a receptor tyrosine kinase, is important for the development of the hematopoietic and immune systems. Activating mutations of FLT3 are now recognized as the most common molecular abnormality in acute myeloid leukemia, and FLT3 mutations may play a role in other hematologic malignancies as well. The poor prognosis of patients harboring these mutations renders FLT3 an obvious target of therapy. This review summarizes the data on the molecular biology and clinical impact of FLT3 mutations, as well as the therapeutic potential of several small-molecule FLT3 inhibitors currently in development.Keywords
This publication has 137 references indexed in Scilit:
- Mutational analysis of class III receptor tyrosine kinases (C‐KIT, C‐FMS, FLT3) in idiopathic myelofibrosisBritish Journal of Haematology, 2003
- Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and childrenBlood, 2002
- The TGFβ Receptor Activation ProcessMolecular Cell, 2001
- Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia ChromosomeNew England Journal of Medicine, 2001
- Crystallographic and Solution Studies of an Activation Loop Mutant of the Insulin Receptor Tyrosine KinasePublished by Elsevier ,2001
- Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine 1 1Edited by I. A. WilsonJournal of Molecular Biology, 1999
- Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal TumorsScience, 1998
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populationsCell, 1991
- Mutation of the Adh gene of Drosophila melanogaster containing an internal tandem duplicationJournal of Molecular Biology, 1985