Effect of Dietary Phosphate Supplements on Dental Caries in the Rat
- 1 July 1962
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 41 (4), 875-882
- https://doi.org/10.1177/00220345620410042001
Abstract
The effect of various dietary phosphates on the occurrence of dental caries in the NMRI-D strain of rat was studied. It was found that the addition of either CaHPO4 or Na2HPO4 to a purified diet resulted in fewer carious teeth, fewer carious lesions and a tendency for the lesions to be less severe than in the unsupplemented control rats. The results with Na2HPO4 were confirmed, and it was found that (NH4)2HPO4 was also an effective cariostatic agent when added to the diet at a level equivalent to the Na salt. Na4P2O7 and Na5P3O10 were not effective. Titration curves of aqueous preparations of the various phosphates showed that Na4P2O7 had the highest pH in solution, and after reaching a pH of about 6.5 it titrated similarly to Na2HPO4 or (NH4)2 HPO4. If the buffering capacity of the various phosphate compounds is the only mechanism of caries reduction, Na4P2O7 would be expected to be effective; since it was not, some possible reasons were discussed.Keywords
This publication has 4 references indexed in Scilit:
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- The Caries-Inhibiting Effects of Na2HPO4 and CaHPO4Journal of Dental Research, 1959
- Dental Caries in the Albino Rat in Relation to the Chemical Composition of the Teeth and of the Diet II. Variations in the Ca/P Ratio of the Diet Induced by Changing the Phosphorus ContentJournal of Nutrition, 1956
- The stability of complexes between calcium and orthophosphate, polymeric phosphate, and phytateArchives of Biochemistry and Biophysics, 1953