Carcinoembryonic antigen (CEA) in the normal human small intestine: a light and electron microscopic study.
Open Access
- 1 October 1977
- Vol. 18 (10), 786-791
- https://doi.org/10.1136/gut.18.10.786
Abstract
An immunoperoxidase method for the demonstration of carcinoembryonic antigen (CEA) in tissues was applied to formalin-fixed paraffin embedded and glutaraldehyde-fixed resin sections of normal human small intestine. CEA could easily be demonstrated coating the surface of the small intestine, lining the crypts, and in goblet cells, indicating its presence there in considerable concentration. At the ultrastructural level CEA was localised in the glycocalyx and in mucin granules of goblet cells but not intracytoplasmically.This publication has 23 references indexed in Scilit:
- Immunohistochemistry of carcinoembryonic antigen: characterisation of cross-reactions with other glycoproteins.Gut, 1977
- CARCINOEMBRYONIC ANTIGEN IN MEDULLARY CARCINOMA OF THYROIDThe Lancet, 1976
- PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATIONJournal of Histochemistry & Cytochemistry, 1974
- Report of the workshop on the carcinoembryonic antigen (CEA): The present position and proposals for future investigationInternational Journal of Cancer, 1974
- Carcinoembryonic antigen (CEA) in feces and plasma of normal subjects and patients with colorectal carcinomaDiseases of the Colon & Rectum, 1974
- Carcinoembryonic antigenic activity of tissue extracts: A quantitative study of malignant and benign neoplasms, cirrhotic liver, normal adult and fetal organsInternational Journal of Cancer, 1973
- Carcinoembryonic Antigen (CEA) in non digestive cancerous and normal tissuesImmunochemistry, 1973
- A routine method for embedding animal tissues in Spurr resin for electron microscopy.Journal of Clinical Pathology, 1973
- MIGRATION OF GLYCOPROTEIN FROM GOLGI APPARATUS TO CELL COAT IN THE COLUMNAR CELLS OF THE DUODENAL EPITHELIUMThe Journal of cell biology, 1970
- SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEMThe Journal of Experimental Medicine, 1965